Profile Detail

Sina Tavakoli, MD, PhD

Assistant Professor

Interest (in 3 to 10 words): Cardiothoracic Radiology

Medical / Graduate School MD: Tehran University of Medical Sciences
PhD: University of Texas Health Science Center at San Antonio
Residency University of Texas Health Science Center at San Antonio
Clinical / Post-doctoral Fellowship Clinical Fellowship: University of Washington
Postdoctoral Fellowship: Yale University & University of Southern California
& Programs
Nuclear Medicine
Clinical Interest - Cardiac and Thoracic Radiology
- Atherosclerotic Plaque Vulnerability
Research Interest - Molecular imaging of cardiovascular disease
- Macrophage metabolism and its implications for 18F-FDG PET imaging of atherosclerosis
- Macrophage biology
Selected Publications   - Tavakoli S, Short JD, Downs K, Nguyen HN, Lai Y, Zhang W, Jerabek P, Goins B, Sadeghi MM, Asmis R. Differential Regulation of Macrophage Glucose Metabolism by M-CSF and GM-CSF: Implications for 18F-FDG PET Imaging of Vessel Wall Inflammation. Radiology. 2017; 283(1):87-97.

- Tavakoli S, Downs K, Short JD, Nguyen HN, Lai Y, Jerabek P, Goins B, Toczek J, Sadeghi MM, Asmis R. Improved Characterization of Macrophage Polarization States Using Combined Measurement of 2-Deoxyglucose and Glutamine Accumulation: Implications for Imaging of Atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 2017. In Press.

- Tavakoli S. Technical considerations for Quantification of 18F-FDG Uptake in Carotid Atherosclerosis. Journal of Nuclear Cardiology (Editorial). 2017. In Press.

- Kim HS, Tavakoli S, Piefer LA, Nguyen HN, Asmis R. Monocytic MKP-1 is a Sensor of the Metabolic Environment and Regulates the Functional and Phenotypic Fate of Monocyte-Derived Macrophages in Atherosclerosis. Scientific Reports. 2016; 27(6):34223.

- Zamora DA, Downs KP, Ullevig SL, Tavakoli S, Kim HS, Qiao M, Greaves DR, Asmis R. Glutaredoxin 2a Overexpression in Macrophages Promotes Mitochondrial Dysfunction but has Little or no Effect on Atherogenesis in LDL-Receptor Null Mice. Atherosclerosis. 2015; 241(1):69-78.

- Tavakoli S, Vashist A, Sadeghi MM. Molecular Imaging of Plaque Vulnerability. Journal of Nuclear Cardiology. 2014; 21(64), 1112-28.

- Tavakoli S, Zamora D, Ullevig S, Asmis R. Bioenergetic Profiles Diverge During Macrophage Polarization: Implications for the Interpretation of 18F-FDG PET Imaging of Atherosclerosis. Journal of Nuclear Medicine. 2013; 54(9): 1661-7.

- Tavakoli S, Asmis R. Reactive Oxygen Species and Thiol Redox Signaling in the Macrophage Biology of Atherosclerosis. Antioxidants & Redox Signaling. 2012;17(12):1785-1795.

- Zhang J, Razavian M, Tavakoli S, Nie L, Tellides G, Backer JM, Backer MV, Bender JR, Sadeghi MM. Molecular Imaging of Vascular Endothelial Growth Factor Receptors in Graft Arteriosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 2012; 32(8):1849-55.

- Restrepo CS, Tavakoli S, Marmol-Velez A. Contrast Enhanced Cardiac Magnetic Resonance Imaging. MRI Clinics of North America. 2012; 20(4):739-60.

- Tavakoli S, Razavian M, Zhang J, Nie L, Marfatia R, Dobrucki LW, Sinusas AJ, Robinson S, Edwards DS, Sadeghi MM. Matrix metalloproteinase activation predicts amelioration of remodeling following dietary modification in injured arteries. Arteriosclerosis, Thrombosis, and Vascular Biology. 2011; 31(1):102-9.

- Razavian M, Tavakoli S, Zhang J, Nie L, Dobrucki LW, Sinusas AJ, Azure M, Robinson S, Sadeghi MM. Atherosclerosis Plaque Heterogeneity and Response to Therapy Detected by In Vivo Molecular Imaging of Matrix Metalloproteinase Activation. Journal of Nuclear Medicine. 2011; 52(11):1795-802.

- Razavian M, Marfatia R, Mongue-Din H, Tavakoli S, Sinusas AJ, Zhang J, Nie L, Sadeghi MM. Integrin-targeted Imaging of Inflammation in Vascular Remodeling. Arteriosclerosis, Thrombosis, and Vascular Biology. 2011; 31(12):2820-6.

- Razavian M, Zhang J, Nie L, Tavakoli S, Razavian N, Dobrucki LW, Sinusas AJ, Edwards DS, Azure M, Sadeghi MM. Imaging Matrix Metalloproteinase Activation to Predict Aneurysm Expansion in vivo. Journal of Nuclear Medicine, 2010; 51(7):1107-15.

- Zhang J, Silva T, Yarovinsky T, Manes T, Tavakoli S, Nie L, Tellides G, Pober JS, Bender JR, Sadeghi, MM. VEGF Blockade Inhibits Lymphocyte Recruitment and Ameliorates Immune-Mediated Vascular Remodeling. Circulation Research, 2010; 107(3):408-17.

- Tavakoli S, Sadeghi MM. Imaging of Vascular Biology in the Heart. Current Cardiovascular Imaging Reports. 2009;2(1):40-9.

Honors and  
2016: RSNA Roentgen Resident/Fellow Research Award
2015: Journal of Radiology Editors Recognition Award for Reviewing with Distinction
2013: RSNA William W. Olmsted Editorial Fellowship
2009: RSNA Young Investigator Award in Molecular Imaging
PubMed Publications   See a listing of publications on PubMed, a service of the National Library of medicine.