PET: Current Projects

Examples of Current Research Projects

Neurology:

  • Brain Amyloid and Cognition in Normal Elderly
  • Natural History of Amyloid Deposition in Adults with Down Syndrome
  • Amyloid Deposition, Vascular Disease, and Clinical Progression of Alzheimer’s Disease
  • In Vivo Neuroimaging Biomarker Panel for Traumatic Brain Injury
  • [18F]AV-1451 Tau imaging in Control, MCI, and AD subjects

Addiction:

  • Imaging of Cortical Dopamine Transmission in Alcohol dependence
  • PET Imaging of Pre-synaptic and Post-synaptic Dopamine Transmission in Cocaine Dependence
  • Imaging the Nociceptin/Orphanin FQ Peptide Receptor (NOP) in Alcoholism with Positron Emission Tomography
  • Linking Nociceptin Opioid Peptide (NOP) Receptors with Relapse in Cocaine use Disorders
  • Linking Cortical Dopamine Transmission with Relapse in Cocaine use Disorders

Mood, Sleep, Aging:

  • Modulators of Cognitive Transition in Normal Aging
  • Testing a Neurobiological Model of Primary Insomnia
  • Neurobiology of Sleep and Sleep Treatment Response in Returning Veterans
  • Effects of CBTI on Functional Anatomy of Sleep in Older Adults with Insomnia

Psychiatry/Psychology:

  • Changes in Serotonin Transporter Binding During Interferon-Alpha Treatment: Use of PET
  • Does Long-term Lithium Treatment Prevent Amyloid in Elders with Bipolar Disorder?
  • Characterization of [11C]flumazenil to Image GABA Transmission in Healthy Adult Subjects
  • Neuroimaging Correlates of Psychomotor Slowing in Patients with Diabetes
  • Maturation of Striatal Function and Neurophysiology Through Adolescence and Young Adulthood: A Multimodal Imaging PET/fMRI Study

Oncology:

  • New Simultaneous Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) Technology for Oncology
  • Quantitative Biomarker Imaging for Early Therapy Response Assessment in Cancer
  • Imaging Assessments of Cellular Proliferation, Vascularity, and Cellular Metabolites in Glioblastoma Multiforme (GBM)

Drug/Treatment Trials:

  • A Phase 3 Extension, Multicenter, Double-Blind, Long Term Safety and Tolerability Trial of Bapineuzumab in Subjects with Alzheimer’s Disease who Participated in Study ELN1152727
  • A Phase I/IIA Study of the Safety and Efficacy of Modified Stromal Cells (SB623) in Subjects with Stable Ischemic Stroke
  • Effect of Passive Immunization on the Progression of Mild Alzheimer’s Disease: Solanezumab (LLY 2062430) Versus Placebo
  • Anti-Amyloid Treatment in Asymptomatic Alzheimer’s Disease (A4) Study
  • DIAN-TU-001: A Phase II/III Randomized, Double-Blind, Placebo-Controlled Multicenter Study of two Potential Disease Modifying Therapies in Individuals at Risk for and with Dominantly Inherited Alzheimer’s Disease
  • A Multicenter, Randomized, Controlled Study to Evaluate the Efficacy and Safety of Short-Term Plasma Exchange Followed by Long-Term Plasmapheresis with Infusion of Human Albumin Combined with Intravenous Immunoglobulin in Patients with Mild to Moderate Alzheimer’s Disease

Participation in Multi-Site Imaging Studies:

  • Alzheimer’s Disease Neuroimaging Initiative-2 (ADNI-2)
  • Dominantly Inherited Alzheimer Initiative (DIAN)
  • Multicenter, Multicountry Study to Calibrate Florbetapir (F18) PET Imaging Data to the Centiloid Scale based on [11C]PiB