Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) study
NIH/NIDDK “Data Coordinating and Imaging Analysis Center (DCIAC)” “Polycystic Kidney Disease: Innovative MR Imaging to Assess Progression”
The major goal of this project is to determine if changes in kidney, kidney cyst, liver and liver cyst volumes, and renal blood flow measured by MR imaging correlate with clinical measures over a short period of time in autosomal dominant polycystic kidney disease.
HALT-PKD research study
NIH/NIDDK “Data Coordinating Center for PKD Treatment Network Supplement”
The objective of this supplemental application is to provide MR imaging measurements of the kidney, liver, liver cyst, and left ventricular wall volumes, and renal blood flow that will be used for outcome measures of the HALT-PKD study in autosomal dominant polycystic kidney disease.
PIPE research study
NIH/ NHLBI “Identifying CT Imaging Biomarkers Associated with Prognosis of Pulmonary Embolism”
The work proposed in this application takes advantage of widely available CTPA imaging biomarker data and extends and advances clinical PE risk prediction model to include long term survival as well as the clinically important outcome of recurrence. We believe the proposed study is timely and will provide a new insight to prognosis and clinical management and treatment of pulmonary embolism.
Knee research study
NIH/ NHLBI “Pivotal OAI MRI Analyses (POMA)”
The overarching purpose of this proposal is to identify structural changes detectable by MRI (i.e., surrogate biomarkers) that precede the onset of radiographic knee osteoarthritis (ROA) and/or that predict the development of important clinical outcomes. Ultimately, this line of research will help to identify key risk factors for the development of osteoarthritis (OA) symptoms and OA structural disease progression.
Parkinson's research study
“Imaging NIH/ NIBIB Biomarkers for Parkinson’s Disease using 7 Tesla MRI”
With the significantly improved image contrast and resolution offered by 7T MR images, we will develop and optimize MR imaging techniques to allow for reliable measurement of deep brain structures in patients with Parkinson disease. This will help advance our understanding of the structure-function relationships in the disease progression of Parkinson disease.
Sodium imaging study
“Sodium/proton MR Imaging of Knee Cartilage in Osteoarthritis“,
this study is addressing a key issue in early detection of knee osteoarthritis using advanced proton and sodium MR imaging techniques at high field. Dual-tuned proton/sodium MR imaging techniques at 7 T take advantage of the improved multi-nuclei signals and spatial resolution for reliable measurement of knee cartilage morphology and tissue sodium signal changes associated with knee osteoarthritis. Reliable imaging biomarkers will contribute to the early detection and optimization of treatment of patients with knee osteoarthritis.